GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2251844 | 1 | rs2255042 | chr15:43834318 | CATSPER2 | chr15:43922774-43959900:- | 0.33 | 5.09 | 5.63E-7 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2255051 | chr15:43846161 | ADAL | chr15:43622872-43646094:+ | -0.43 | -5.28 | 2.12E-7 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2255051 | chr15:43846161 | CATSPER2 | chr15:43922774-43959900:- | -0.33 | -5.21 | 3.04E-7 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2255440 | chr15:43830467 | ADAL | chr15:43622872-43646094:+ | -0.42 | -5.21 | 3.03E-7 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2255440 | chr15:43830467 | CATSPER2 | chr15:43922774-43959900:- | -0.31 | -4.87 | 1.63E-6 | Tumor biomarkers |
| BLCA | cis | rs2555155 | 1 | rs2256920 | chr11:6508124 | RRP8 | chr11:6621154-6624811:- | -0.21 | -3.93 | 9.92E-5 | DNA methylation (variation) |
| BLCA | cis | rs2243480 | 1 | rs2257790 | chr7:65600450 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.46 | 1.07E-5 | Diabetic kidney disease |
| BLCA | cis | rs2251844 | 1 | rs2260160 | chr15:43895643 | ADAL | chr15:43622872-43646094:+ | -0.36 | -4.21 | 3.21E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2260160 | chr15:43895643 | CATSPER2 | chr15:43922774-43959900:- | -0.32 | -4.86 | 1.74E-6 | Tumor biomarkers |
| BLCA | cis | rs11622475 | 1 | rs2269186 | chr14:104379912 | TDRD9 | chr14:104394817-104519002:+ | 0.34 | 5.55 | 5.28E-8 | Bipolar disorder |
| BLCA | cis | rs5770917 | 1 | rs2269381 | chr22:51020069 | CPT1B | chr22:51007291-51017096:- | -0.38 | -3.9 | 0.000112 | Narcolepsy |
| BLCA | cis | rs763014 | 1 | rs2269558 | chr16:682250 | WFIKKN1 | chr16:679239-684116:+ | 0.29 | 5.46 | 8.46E-8 | Height |
| BLCA | cis | rs9815354 | 1 | rs2272006 | chr3:41997059 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.76 | 2.93E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs2272007 | chr3:41996136 | ULK4 | chr3:41288091-42003660:- | -0.65 | -10.12 | 1.79E-21 | Diastolic blood pressure |
| BLCA | cis | rs6715284 | 1 | rs2272390 | chr2:202195311 | PPIL3 | chr2:201735680-201753999:- | -0.44 | -3.91 | 0.000109 | Rheumatoid arthritis |